N-halamine Chemistry for Antimicrobial Efficacy
The first, and arguably most important chemistry, is the antimicrobial chemistry of N-halamine. Under development at Auburn University for the last 30 years, N-halamine represents the first new antimicrobial chemistry in a century. Even so, N-halamine is not new way to kill pathogens because the molecule relies on chlorine for effectiveness. We have used chlorine for hundreds of years in our drinking water, our pools, our laundry and our cleaners and disinfectants. The rest of the N-halamine molecule serves only to stabilize chlorine in a safe and active state.
Covalently bonds to chlorine
Preferentially kills pathogens
Already used for drinking water purification
Safe to the touch
Zwitterion Chemistry for Anti-Fouling Efficacy
A zwitterion is a molecule that has at least two functional groups: one having a positive charge and the other having a negative charge, with an overall charge of zero. Zwitterions interact with water molecules and essentially form a water barrier that makes it hard for proteins to stick to a surface. Zwitterion chemistry has allowed Cornell researchers to demonstrate that an implanted device can evade the human body’s immune system for several months. Cornell University is one of the leaders in employing zwitterion technology.
Forms water barrier
Retards accumulation of proteins and pathogens
Safe, used on medical devices
Combining these two technology with adhesion chemistry and hydrogel chemistry has allowed Halomine to create a portfolio of products from HaloFilm, an antimicrobial surface coating that holds chlorine on a surface for days, to HaloCare, a wide product offering of advanced wound dressings that are both antimicrobial and anti-adhesion for a variety of applications, to HaloCoat, whose main focus is coating urinary catheters to decrease catheter-associated urinary tract infections.
Thank You to Our Academic Partners
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